L-669,262, A POTENT HMG-COA REDUCTASE INHIBITOR

被引：8
|
作者：
JOSHUA, H
SCHWARTZ, MS
WILSON, KE
机构：
[1] Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065, Inc., P. O. Box 2000
来源：
JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 03期
关键词：
D O I：
10.7164/antibiotics.44.366
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme. A reductase found to date.
引用
收藏
页码：366 / 370
页数：5
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