APOPTOSIS INDUCED IN MOUSE HEPATITIS VIRUS-INFECTED CELLS BY A VIRUS-SPECIFIC CD8(+) CYTOTOXIC T-LYMPHOCYTE CLONE

被引：27
|
作者：
SHIBATA, S
KYUWA, S
LEE, SK
TOYODA, Y
GOTO, N
机构：
[1] UNIV TOKYO,INST MED SCI,DEPT ANIM PATHOL,TOKYO 108,JAPAN
[2] UNIV TOKYO,FAC AGR,VET PATHOL LAB,TOKYO 113,JAPAN
来源：
JOURNAL OF VIROLOGY | 1994年 / 68卷 / 11期
关键词：
D O I：
10.1128/JVI.68.11.7540-7545.1994
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured,vith cloned mouse hepatitis virus-specific CD8(+) cytotoxic T lymphocytes were examined by electron microscopy. Condensation and margination of chromatin, cellular shrinkage with severe vacuolar degeneration, and blebbing were observed. In addition, fragmentation of cellular DNA was observed, and a decrease in virus titer was accompanied by those changes. These findings show that the cloned cytotoxic T lymphocytes induce in the target cell an internal degradation program termed apoptosis, which results in virus clearance.
引用
收藏
页码：7540 / 7545
页数：6
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