EVIDENCE FOR A ROLE OF ANTIIDIOTYPIC ANTIBODIES IN THE INDUCTION OF REMISSION IN GRAVES-DISEASE

被引：4
|
作者：
PASCHKE, R
TEUBER, J
ENGER, I
SCHMEIDL, R
SCHWEDES, U
USADEL, KH
机构：
[1] II. Medical Clinic, Klinikum Mannheim, University of Heidelberg
来源：
JOURNAL OF AUTOIMMUNITY | 1990年 / 3卷 / 04期
关键词：
D O I：
10.1016/S0896-8411(05)80011-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Serum and Ig samples obtained from a patient with Graves' disease during exacerbation and remission were evaluated in the nu/nu bioassay. Blocking of the exacerbation serum's biological activity was demonstrated by several biological assay parameters after it was mixed with the remission serum. Since this blocking effect can be ascribed to immunoglobulins, anti-idiotypic antibodies in the remission serum and immunoglobulin samples are the most likely cause of this blocking effect. Therefore a role of anti-idiotypic antibodies in the induction of remission in Graves' disease is postulated. © 1990 Academic Press Limited.
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收藏
页码：441 / 448
页数：8
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