CHARACTERIZATION OF A NOVEL BINDING-SITE FOR THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE PROTEIN GP120 ON HUMAN FETAL ASTROCYTES

被引：71

作者：

MA, MH

GEIGER, JD

NATH, A

机构：

[1] UNIV MANITOBA,DEPT MED MICROBIOL,WINNIPEG R3E 0W3,MB,CANADA

[2] UNIV MANITOBA,DEPT PHARMACOL & THERAPEUT,WINNIPEG R3E 0W3,MB,CANADA

[3] UNIV MANITOBA,DEPT INTERNAL MED,NEUROL SECT,WINNIPEG R3E 0W3,MB,CANADA

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 10期

关键词：

D O I：

10.1128/JVI.68.10.6824-6828.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

I-125-labeled recombinant gp120 bound to primary cultures of human fetal astrocytes,vith a single class of 260-kDa binding sites, with a K-d of 26 nM and maximal number of binding sites of 29.9 fmol/4 x 10(4) cells. Neither CD4 nor galactocerebroside was detectable on astrocytes, and I-125-labeled recombinant gp120 binding to astrocytes was not blocked by antibodies against galactocerebroside or the gp120 binding domain of CD4.

引用

页码：6824 / 6828

页数：5

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