ACUTE MYELOMONOCYTIC LEUKEMIA WITH BONE-MARROW EOSINOPHILIA AND INV(16)(P13Q22),T(1-16)(Q32-Q22)

被引：20
|
作者：
YIP, MY [1 ]
SHARMA, P [1 ]
WHITE, L [1 ]
机构：
[1] PRINCE WALES CHILDRENS HOSP, DEPT HAEMATOL ONCOL, SYDNEY, AUSTRALIA
来源：
CANCER GENETICS AND CYTOGENETICS | 1991年 / 51卷 / 02期
关键词：
D O I：
10.1016/0165-4608(91)90136-I
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A two-year-old girl presenting with de novo acute myelomonocytic leukemia with eosinophilia (French-American-British [FAB] classification, M4Eo) and inv(16)(p13q22), t(1;16)(q32;q22) involving the same chromosome 16 is described. This is the second report of a variant translocation of an inverted chromosome 16 with chromosome 1 at 1q32. However, the segment 1q32 --> 1qter has been exchanged for 16q22 --> qter and not 16p13 --> pter, as reported in the previous case. The additional break at 1q32 and the juxtaposition of 1q32 --> qter onto chromosome 16 could be relevant to the pathogenesis of the disease.
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收藏
页码：235 / 238
页数：4
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