SYNTHESIS AND CYTOTOXICITY OF 4-[(E)-HETARYL-VINYL]-6,6-DIMETHYL-2-OXO-1,2,5,6-TETRAHYDRO-PYRIDINE-3-NITRILES

被引：0

作者：

Jansone, Daina ^{[1
]}

Popelis, Juris ^{[1
]}

Jaschenko, Elina ^{[1
]}

Gulbe, Anita ^{[1
]}

Shestakova, Irina ^{[1
]}

Fleisher, Mendel ^{[1
]}

Belyakov, Sergey ^{[1
]}

Abele, Edgars ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, 21 Aizkraukles St, LV-1006 Riga, Latvia

来源：

HETEROCYCLIC LETTERS | 2012年 / 2卷 / 02期

关键词：

4,6,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyridine-3-nitrile; 4-[(E)-hetaryl-vinyl]-6,6dimethyl; 2-oxo-1,2,5,6-tetrahydro-pyridine-3-nitriles; heteroaromatic aldehydes; condensation; cytotoxicity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A detailed investigation of condensation of 4,6,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyridine-3nitrile with heteroaromatic aldehydes in the presence of catalytic amounts of NaOH in EtOH was presented. 4-[(E)-Hetaryl-vinyl]-6,6-dimethyl-2-oxo-1,2,5,6-tetrahydro-pyridine-3-nitriles were isolated in 50-97 % yields. The cytotoxicity of studied compounds towards HT-1080 (human fibrosarcoma), MG22A (mouse hepatoma) and 3T3 (mouse embryonic fibroblasts) was described. 4-[(E)-2-(6-Bromo-2-pyridyl)-vinyl]-6,6-dimethyl-2-oxo-1,2,5,6-tetrahydro-pyridine3- nitrile exhibit high activity against MG-22A cancer cell line.

引用

页码：198 / 205

页数：8

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