SYNTHESIS OF O-BETA-D-GALACTOPYRANOSYL-(1-3)-O-BETA-D-GALACTOPYRANOSYL-(1-4)-O-BETA-D-XYLOPYRANOSYL-(1-3)-L-SERINE (GAL-GAL-XYL-SER)

被引：23

作者：

EKBORG, G

CURENTON, T

KRISHNA, NR

RODEN, L

机构：

[1] UNIV ALABAMA,MED GENET LAB,BIRMINGHAM,AL 35294

[2] UNIV ALABAMA,CTR NMR CORE FACIL COMPREHENS CANC,BIRMINGHAM,AL 35294

[3] UNIV ALABAMA,DEPT BIOCHEM,BIRMINGHAM,AL 35294

[4] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1990年 / 9卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1080/07328309008545795

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

O-β-D-Galactopyranoayl-(1—>3)-O-β-D-galactopyranosyl-(1—>4)-O-β-D-xylopyranosyl-(1—>3)-L-serine (Gal-Gal-Xyl-Ser) was prepared by a procedure involving the synthesis of a benzoylated galactobiosyl bromide and a xylosylserine derivative with an unsubstituted hydroxyl group at C-4 (3-0-(2, 3-di-O-benzoyl-β-D-xylopyranosyl)-N-carbobenzoxy-L-serine benzyl ester), followed by condensation and deblocking. The structure of the product was confirmed by 1H-and 13C-NMR spectroscopy. Upon incubation with an extract of embryonic chick cartilage, the synthetic Gal-Gal-Xyl-Ser served as an acceptor for enzymatic glucuronosyl transfer from UDP-D-glucuronic acid. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：15 / 37

页数：23

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