GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED CD4 SUPPORTS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION, BUT NOT CYTOPATHIC EFFECT, IN T-CELL TRANSFECTANTS

被引：5

作者：

MARSHALL, WL ^{[1
]}

MITTLER, ES ^{[1
]}

AVERY, P ^{[1
]}

LAWRENCE, JP ^{[1
]}

FINBERG, RW ^{[1
]}

机构：

[1] DANA FARBER CANC INST,DIV INFECT DIS,BOSTON,MA 02115

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 06期

关键词：

D O I：

10.1128/JVI.68.6.4039-4042.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Despite equivalent p24 antigen production, HSB-2 T cells ex-pressing glycosylphosphatidylinositol (GPi)linked CD4 were productively infected without cell death or syncytium formation, unlike HSB-2 transfectants expressing wild-type CD4 (wtCD4). HSB-2 transfectants dually expressing wtCD4 and GPi-linked CD4 formed syncytia and died. Thus, wtCD4 expression is critical for human immunodeficiency virus cytopathic effect in HSB-2 transfectants.

引用

页码：4039 / 4042

页数：4

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