GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED CD4 SUPPORTS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION, BUT NOT CYTOPATHIC EFFECT, IN T-CELL TRANSFECTANTS

被引：5
|
作者：
MARSHALL, WL [1 ]
MITTLER, ES [1 ]
AVERY, P [1 ]
LAWRENCE, JP [1 ]
FINBERG, RW [1 ]
机构：
[1] DANA FARBER CANC INST,DIV INFECT DIS,BOSTON,MA 02115
来源：
JOURNAL OF VIROLOGY | 1994年 / 68卷 / 06期
关键词：
D O I：
10.1128/JVI.68.6.4039-4042.1994
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Despite equivalent p24 antigen production, HSB-2 T cells ex-pressing glycosylphosphatidylinositol (GPi)linked CD4 were productively infected without cell death or syncytium formation, unlike HSB-2 transfectants expressing wild-type CD4 (wtCD4). HSB-2 transfectants dually expressing wtCD4 and GPi-linked CD4 formed syncytia and died. Thus, wtCD4 expression is critical for human immunodeficiency virus cytopathic effect in HSB-2 transfectants.
引用
收藏
页码：4039 / 4042
页数：4
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