GERM-LINE ORIGIN OF FUNCTIONAL IDIOTYPIC INTERACTIONS - IDENTIFICATION OF 2 IDIOTYPICALLY CONNECTED, NATURAL ANTIBODIES THAT ARE ENCODED BY GERM-LINE GENE ELEMENTS

被引：7
|
作者：
CARLSSON, L [1 ]
ANDERSSON, A [1 ]
HOLMBERG, D [1 ]
机构：
[1] UMEA UNIV,APPL CELL & MOLEC BIOL UNIT,S-90187 UMEA,SWEDEN
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 09期
关键词：
D O I：
10.1002/eji.1830210944
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two monoclonal, natural IgM antibodies derived from normal BALB/c mice were selected on the basis of being idiotypically complementary and functionally connected. Nucleotide sequence analysis of their respective heavy and light chain V regions showed that both of the clones expressed V(H), D, J(H), V(L) and J(L) gene segments of germ-line origin. Furthermore, none of the clones displayed N-sequence additions. These data suggest a germ-line origin of a functional idiotypic network and confirm a minimized contribution of somatic diversification through template-independent addition of N-nucleotides in neonatal B cell repertoires.
引用
收藏
页码：2285 / 2288
页数：4
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