FEATURES OF THE GENETIC POLYMORPHISM OF ARYLAMINE N-ACETYLTRANSFERASE 2 IN PATIENTS WITH PULMONARY TUBERCULOSIS IN KHARKIV REGION

被引：0
|
作者：
Lebid, L., V [1 ]
Kireev, I., V [1 ]
Ljashenko, A. A. [1 ]
机构：
[1] Natl Pharmaceut Univ, Kharkiv Med Acad, Postgrad Edu, Kharkov, Ukraine
来源：
WORLD OF MEDICINE AND BIOLOGY | 2015年 / 48卷 / 01期
关键词：
pulmonary tuberculosis; NAT2; gene polymorphism;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
patients with pulmonary tuberculosis in the Kharkov region, Ukraine 5 SNPs of NAT2 were determined including C282T, C481T, G590A, A803G and G857A. Materials and methods. The research group consisted of 27 Caucasians with different types and prevalence of tuberculosis process, with different sensitivity of Mycobacterium tuberculosis to anti-TB drugs and different treatment efficacy. In the Caucasian population of Kharkiv region, Ukraine there is no association of polymorphic variants C282T, S481T, G590A and G857A gene NAT2 with clinical manifestations of pulmonary tuberculosis. "Wild" type 803A is associated with a predisposition to severe extensive forms of the smear positive tuberculosis.
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页码：43 / 46
页数：5
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