IMMUNOHISTOCHEMICAL STAINING OF FELINE MALIGNANT FIBROUS HISTIOCYTOMAS

被引:13
|
作者
PACE, LW
KREEGER, JM
MILLER, MA
TURK, JK
FISCHER, JR
机构
[1] Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO
关键词
MALIGNANT FIBROUS HISTIOCYTOMA; CATS; IMMUNOHISTOCHEMISTRY;
D O I
10.1177/030098589403100202
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Malignant fibrous histiocytoma was diagnosed in seven cats from biopsy specimens received at the University of Missouri Veterinary Medical Diagnostic Laboratory during a 4-year period from 1987-1991. Tissue blocks from formalin-fixed specimens were resectioned and stained for type I (AE1) and type II (AE3) cytokeratins, desmin, S100 protein, vimentin, and alpha(1)-antitrypsin by the avidin biotin peroxidase complex method with diaminobenzidine (DAB) chromogen. None of the tumors stained positively for alpha(1)-antitrypsin. Four of seven of the tumors had similar immunohistochemical staining results, with positive staining for type I and type II cytokeratins, desmin, S100 protein, and vimentin. Of the remaining three, one stained positively only for S100 protein and vimentin; one stained positively for vimentin only; and one was negative for all six antigens. Based only on immunohistochemical staining results, three of the tumors could possibly be reclassified: one as a melanoma, one as a probable fibrosarcoma, and one as unknown. These results also indicate that feline malignant fibrous histiocytomas show a diversity of intermediate filament expression, as do human tumors. Our results also do not support the theory that malignant fibrous histiocytomas are of histiocytic origin.
引用
收藏
页码:168 / 172
页数:5
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