COMPARISON OF THE SUSCEPTIBILITY OF THE RED FOX (VULPES-VULPES) TO A VACCINIA-RABIES RECOMBINANT VIRUS AND TO COWPOX VIRUS

被引：23
|
作者：
BOULANGER, D
BROCHIER, B
CROUCH, A
BENNETT, M
GASKELL, RM
BAXBY, D
PASTORET, PP
机构：
[1] UNIV LIEGE, FAC VET MED, DEPT IMMUNOL VACCINOL, B-4000 LIEGE, BELGIUM
[2] UNIV LIVERPOOL, DEPT VET CLIN SCI, LIVERPOOL L69 3BX, MERSEYSIDE, ENGLAND
[3] UNIV LIVERPOOL, DEPT VET PATHOL, LIVERPOOL L69 3BX, MERSEYSIDE, ENGLAND
[4] UNIV LIVERPOOL, DEPT MED MICROBIOL, LIVERPOOL L69 3BX, MERSEYSIDE, ENGLAND
来源：
VACCINE | 1995年 / 13卷 / 02期
关键词：
RABIES VIRUS; COWPOX VIRUS; RECOMBINATION RISK;
D O I：
10.1016/0264-410X(95)93139-Z
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sylvatic rabies can be efficiently controlled by vaccination of foxes with a vaccinia-rabies recombinant virus. However, the risk of recombination between the engineered vaccine virus and other orthopoxviruses endemic in wildlife, such as cowpox virus, still needs to be investigated. In this study, foxes inoculated orally and intradermally with cowpox virus were found to be not very susceptible to cowpox virus, which was isolated from only the oropharynx and tonsils, at low titre and for only five days after inoculation. Thus the risk of recombination between these viruses in foxes is very low.
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页码：215 / 219
页数：5
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