MECHANISTIC INFORMATION ON THE REACTION OF MODEL PALLADIUM(II) COMPLEXES WITH PURINE NUCLEOSIDES AND 5'-NUCLEOTIDES IN REFERENCE TO THE ANTITUMOR-ACTIVITY OF RELATED PLATINUM COMPLEXES

被引：25

作者：

SHOUKRY, M ^{[1
]}

HOHMANN, H ^{[1
]}

VANELDIK, R ^{[1
]}

机构：

[1] UNIV WITTEN HERDECKE, INST INORGAN CHEM, STOCKUMER STR 10, W-5810 WITTEN, GERMANY

来源：

INORGANICA CHIMICA ACTA | 1992年 / 198卷

关键词：

D O I：

10.1016/S0020-1693(00)92360-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reaction of Pd(Me,en)Cl2 (Me4en=NNN',N'-tetramethylethylenediamine) with inosine and 5'-inosine monophosphate was studied as a function of chloride concentration and pH. Evidence for the formation of a 1:1 complex with these nucleophiles is presented, and the kinetic data indicate that Pd(Me4en)(Cl)H2O+ is the only reactive species under the selected experimental conditions. The results are compared to earlier data for the reactions of Pd(R4en)(H2O)22+ (R = H, Me, Et) with a series of nucleosides and 5'-nucleotides. The dependencies studied in this investigation allow some tentative extrapolations to conditions relevant for the antitumor activity of related Pt(II) complexes.

引用

页码：187 / 192

页数：6

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