ASSESSMENT OF ELECTROPHORETIC MOBILITY CHANGES OF HUMAN ERYTHROCYTES BY FREE-FLOW ELECTROPHORESIS AFTER INVITRO AND INVIVO IRRADIATION

被引：2
|
作者：
SCHREIBER, GA [1 ]
SPIEGELBERG, A [1 ]
BUTKOWSKYJWALKIW, T [1 ]
BOGL, KW [1 ]
机构：
[1] BUNDESGESUNDHEITSAMT,INST STRAHLENHYG,W-8042 NEUHERBERG,GERMANY
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1990年 / 17卷 / 04期
关键词：
D O I：
10.1016/0883-2897(90)90104-9
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Single cell measurements of electrophoretic mobility showed a linear dose-response of human erythrocytes after exposure to ionizing radiation. To establish a biological indicator- or dosimeter-system for application to dose-estimations after accidental exposures, we tried to measure dose dependent EPM-changes by the free flow electrophoresis technique, a rapid and efficient method which supplies the capacity needed for application. The in vitro irradiated erythrocytes of most donors showed an oscillating dose-response but erythrocytes from several other individuals responded in a contradictory manner whereby the EPM of erythrocytes from radiotherapy patients increased linearly with the amount of administered dose. However, the wide interindividual EPM-range of unirradiated erythrocytes inhibits the application of this technique in biological dosimetry. © 1990.
引用
收藏
页码：377 / 380
页数：4
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