CA2+-DEPENDENT K+ CHANNEL ACTIVITY IN RAT GLIOMA-CELLS INDUCED BY BRADYKININ STIMULATION AND BY INOSITOL 1,4,5-TRISPHOSPHATE INJECTION

被引：3
|
作者：
BINMOLLER, FJ
REISER, G
机构：
[1] Physiologisch-chemisches Institut, Universität Tübingen, Tübingen, 72076
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 1993年 / 13卷 / 06期
关键词：
BRADYKININ; GLIOMA; NEUROPEPTIDE; INOSITOLPHOSPHATE; K+ CHANNEL;
D O I：
10.1007/BF00711561
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. A glial cell line derived from C6 rat glioma eels has been shown previously to respond to extracellular pulses of bradykinin or intracellular injection of inositol 1,4,5-trisphosphate (Ins-P-3) with a slow hyperpolarizing response due to activation of a K+ current (G. Reiser ef al., Brain Res. 506, 205-214; 1990). 2. We determined the ensuing single-channel activity, which is most likely caused by Ca2+ released from internal stores after bradykinin stimulation. Bradykinin-activated channels were selectively permeable to K+, but not to Na+ or to Cl-, and exhibited conductances of mainly 40 and 50 pS. In glioma cells the same type of channel was activated by intracellular injection of Ins-P-3 and by extracellular bradykinin pulses.
引用
收藏
页码：615 / 624
页数：10
相关论文
共 50 条
  • [41] Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+
    Adkins, CE
    Taylor, CW
    CURRENT BIOLOGY, 1999, 9 (19) : 1115 - 1118
  • [42] Regulation of the miniature plasma membrane Ca2+ channel Imin by inositol 1,4,5-trisphosphate receptors
    Zubov, AI
    Kaznacheeva, EV
    Nikolaev, AV
    Alexeenko, VA
    Kiselyov, K
    Muallem, S
    Mozhayeva, GN
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) : 25983 - 25985
  • [43] RELEASE OF INTRACELLULARLY STORED CA-2+ BY INOSITOL 1,4,5-TRISPHOSPHATE - AN OVERVIEW
    YAMAMOTO, H
    KANAIDE, H
    GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1990, 21 (04): : 387 - 393
  • [44] The basolateral Ca2+-dependent K+ channel in rat colonic crypt cells
    Nielsen M.S.
    Warth R.
    Bleich M.
    Weyand B.
    Greger R.
    Pflügers Archiv, 1997, 435 (2): : 267 - 272
  • [45] Atrial local Ca2+ signaling and inositol 1,4,5-trisphosphate receptors
    Kim, Joon-Chul
    Son, Min-Jeong
    Subedi, Krishna P.
    Li, Yuhua
    Ahn, Joung Real
    Woo, Sun-Hee
    PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2010, 103 (01): : 59 - 70
  • [46] The basolateral Ca2+-dependent K+ channel in rat colonic crypt cells
    Nielsen, MS
    Warth, R
    Bleich, M
    Weyand, B
    Greger, R
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1998, 435 (02): : 267 - 272
  • [47] REQUIREMENT OF CA-2+ FOR THE PRODUCTION AND DEGRADATION OF INOSITOL 1,4,5-TRISPHOSPHATE IN MACROPHAGES
    KUKITA, M
    HIRATA, M
    KOGA, T
    BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 885 (01) : 121 - 128
  • [48] The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca2+-release channel
    Vervloessem, Tamara
    Yule, David I.
    Bultynck, Geert
    Parys, Jan B.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2015, 1853 (09): : 1992 - 2005
  • [49] Modulation of inositol 1,4,5-trisphosphate binding to the recombinant ligand-binding site of the type-1 inositol 1,4,5-trisphosphate receptor by Ca2+ and calmodulin
    Sipma, H
    De Smet, P
    Sienaert, I
    Vanlingen, S
    Missiaen, L
    Parys, JB
    De Smedt, H
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) : 12157 - 12162
  • [50] Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity?
    Wang, Liwei
    Alzayady, Kamil J.
    Yule, David I.
    JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (11): : 2867 - 2876
12345