CA2+-DEPENDENT K+ CHANNEL ACTIVITY IN RAT GLIOMA-CELLS INDUCED BY BRADYKININ STIMULATION AND BY INOSITOL 1,4,5-TRISPHOSPHATE INJECTION

被引：3
|
作者：
BINMOLLER, FJ
REISER, G
机构：
[1] Physiologisch-chemisches Institut, Universität Tübingen, Tübingen, 72076
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 1993年 / 13卷 / 06期
关键词：
BRADYKININ; GLIOMA; NEUROPEPTIDE; INOSITOLPHOSPHATE; K+ CHANNEL;
D O I：
10.1007/BF00711561
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. A glial cell line derived from C6 rat glioma eels has been shown previously to respond to extracellular pulses of bradykinin or intracellular injection of inositol 1,4,5-trisphosphate (Ins-P-3) with a slow hyperpolarizing response due to activation of a K+ current (G. Reiser ef al., Brain Res. 506, 205-214; 1990). 2. We determined the ensuing single-channel activity, which is most likely caused by Ca2+ released from internal stores after bradykinin stimulation. Bradykinin-activated channels were selectively permeable to K+, but not to Na+ or to Cl-, and exhibited conductances of mainly 40 and 50 pS. In glioma cells the same type of channel was activated by intracellular injection of Ins-P-3 and by extracellular bradykinin pulses.
引用
收藏
页码：615 / 624
页数：10
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