ENHANCED IMMUNOGENICITY OF LEUCINE-ENKEPHALIN FOLLOWING COUPLING TO ANTIIMMUNOGLOBULIN AND ANTI-CD3 ANTIBODIES

被引：0
|
作者：
HENDRICKSON, TL
WILSON, GS
FRAZER, JM
LIU, RS
MCCORMACK, RT
WOLFERT, RL
机构：
[1] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66045
[2] HYBRITECH INC,SAN DIEGO,CA 92121
来源：
JOURNAL OF IMMUNOLOGICAL METHODS | 1994年 / 172卷 / 02期
关键词：
MONOCLONAL ANTIBODY; LEUCINE ENKEPHALIN; ANTIIMMUNOGLOBULIN; ANTI-CD3;
D O I：
10.1016/0022-1759(94)90103-1
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Leucine enkephalin (Leu-enk) was coupled to both T and B cell antibodies in order to investigate the possibility of enhanced immunogenicity via targeted immunization. The two antibodies used were Hm x Mo CD3 and Gt x Mo Ig, respectively. The data indicate that while both antibody carriers enhanced the immunogenicity of Leu-enk, the use of the Hm x Mo CD3 antibody resulted in a greater number of mice with positive Leu-enk specific serum titers. 12 Leu-enk cell lines were produced and one, LE4H8, was chosen for characterization.
引用
收藏
页码：165 / 172
页数：8
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