SYNTHESIS, DOCKING AND BIOLOGICAL EVALUATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES

被引：0

作者：

Deshmane, Sonali R. ^{[1
]}

Landge, Deepak K. ^{[1
]}

Bamane, Rohan V. ^{[1
]}

Chitre, Trupti S. ^{[1
]}

Kamble, Sumit B. ^{[1
]}

机构：

[1] AISSMS Coll Pharm, Dept Med Chem, Kennedy Rd, Pune 411001, Maharashtra, India

来源：

HETEROCYCLIC LETTERS | 2013年 / 3卷 / 01期

关键词：

Antimycobacterial; Docking; MABA; Enoyl-acyl carrier protein reductase;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the present study, a novel series of 1,4-dihydropyridine derivatives were synthesized and docking study was performed to rationalize the possible interactions between the synthesized compounds and active site. 1,4-dihydropyridine derivatives were designed as Enoyl-acyl carrier protein reductase inhibitors. All compounds were screened for antimycobacterial activity against M. tuberculosis H37Rv using Microplate Alamar Blue Assay. Pyrazinamide (PZA) and Streptomycin were employed as the reference antimycobacterial agents. Among the series S1 found to be most potent while S2, S3, S4, S5, S6 were found to be less potent than S1.

引用

页码：61 / 68

页数：8

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