EFFECT OF GLUTAMATE AND ITS ANALOGS ON DIACYLGLYCEROL AND MONOACYLGLYCEROL LIPASE ACTIVITIES OF NEURON-ENRICHED CULTURES

被引：32
|
作者：
FAROOQUI, AA [1 ]
ANDERSON, DK [1 ]
HORROCKS, LA [1 ]
机构：
[1] VET ADM MED CTR, CINCINNATI, OH 45220 USA
来源：
BRAIN RESEARCH | 1993年 / 604卷 / 1-2期
关键词：
N-METHYL-D-ASPARTATE; ARACHIDONATE; CALCIUM; DIACYLGLYCEROL LIPASE; MONOACYLGLYCEROL LIPASE;
D O I：
10.1016/0006-8993(93)90366-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neuron-enriched cultures from fetal mouse spinal cord contain diacylglycerol and monoacylglycerol lipases. The treatment of neuron-enriched cultures with glutamate or NMDA resulted in a dose- and time-dependent stimulation in diacylglycerol and monoacylglycerol lipase activities. The elevation in the activities of lipases was blocked by the NMDA receptor antagonists, dextrorphan and MK-801, suggesting that lipase stimulation is a receptor-mediated process. The treatment of neuron-enriched cultures with kainate had no effect on diacylglycerol and monoacylglycerol lipase activities. The stimulation of diacylglycerol and monoacylglycerol lipase activities by glutamate and NMDA suggests that these enzymes may play an important role in processes mediated by the NMDA type of the glutamate receptors.
引用
收藏
页码：180 / 184
页数：5
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