CANDIDATE PROTOONCOGENE BCL-3 ENCODES A SUBUNIT-SPECIFIC INHIBITOR OF TRANSCRIPTION FACTOR NF-KAPPA-B

被引：221
|
作者：
WULCZYN, FG [1 ]
NAUMANN, M [1 ]
SCHEIDEREIT, C [1 ]
机构：
[1] MAX PLANCK INST MOLEC GENET,OTTO WARBURG LAB,IHNESTR 73,W-1000 BERLIN 33,GERMANY
来源：
NATURE | 1992年 / 358卷 / 6387期
关键词：
D O I：
10.1038/358597a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
THE NF-kappa-B subunits p50 and p65 and the product of the rel proto-oncogene are members Of a growing class of transcription factors with a unique DNA-binding and dimerization domain1-13. Nuclear transfer of each of these factors is controlled by cytoplasmic inhibitors, and regulated by specific stimuli. The inhibitors I-kappa-B-alpha and -beta and pp40 recognize either p65 or the c-rel protein14-16. We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias17, encodes a protein that functions as an I-kappa-B-like molecule for native NF-kappa-B but is specific for the p50 subunit. The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-kappa-B dimers by contacting the conserved dimerization domain of NF-kappa-B.
引用
收藏
页码：597 / 599
页数：3
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