NUCLEOSIDES AND NUCLEOTIDES .130. THE SYNTHESIS OF IMIDAZO[4,5-E][1,4]DIAZEPINE NUCLEOSIDES FROM N-1-SUBSTITUTED INOSINES

被引：6
|
作者：
AOYAGI, M [1 ]
MINAKAWA, N [1 ]
MATSUDA, A [1 ]
机构：
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO 060,JAPAN
来源：
NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 6-7期
关键词：
D O I：
10.1080/15257779408012169
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New synthetic methods for pyrimidine ring-expanded xanthosine, guanosine, and inosine analogues containing imidazo[4,5-e][1,4]diazepine nucleus are described. Treatment of N-1-substituted inosine derivatives 5, 12, 19 with aqueous NaOH gave 5-amino-4-(N-substituted carbamoyl)imidazole derivatives, followed by appropriate manipulations to cyclize these to constitute imidazo[4,5-e][1,4]diazepine nucleosides 11, 17, 22.
引用
收藏
页码：1535 / 1549
页数：15
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