REACTION OF (Z)-NARCEINE IMIDE WITH 1,2-EPOXYPROPANE

被引：2
|
作者：
PROKSA, B
机构：
[1] Department of Biochemical Technology, Faculty of Chemistry, Technical University, Bratislava
来源：
MONATSHEFTE FUR CHEMIE | 1993年 / 124卷 / 8-9期
关键词：
(Z)-NARCEINE IMIDE; 1,2-EPOXYPROPANE; NARCEONIC ACID; ACID CYCLIZATION;
D O I：
10.1007/BF00816418
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Z)-Narceine imide (1) reacted with 1,2-epoxypropane to narceone imide (2) and with an excess of epoxide to N-(2-hydroxypropyl)narceone imide (3). Cyclization of 3 in acidic media afforded two isomers of 8,14-dimethyl-11,12-methylenedioxy-3,4,10-trimethoxyindano[1',2':2,3]morpholino-[3,4-a]isoindolin-5-ones 16 and 17 which differed in the spatial orientation of the C-8-CH3. Narceonic acid (18) cyclized into the isochroman-3-spiro-3'-phthalide derivative 19.
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页码：953 / 957
页数：5
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