THE HYPOGLYCEMIC SULFONYLUREA TOLBUTAMIDE INCREASES N-METHYL-D-ASPARTATE- BUT NOT KAINATE-ACTIVATED CURRENTS IN HIPPOCAMPAL-NEURONS IN CULTURE

被引:2
|
作者
KWIECIEN, R [1 ]
MEDINA, I [1 ]
BARBIN, G [1 ]
BENARI, Y [1 ]
机构
[1] INSERM,U29,NEUROBIOL & PHYSIOPATHOL DEV LAB,F-75014 PARIS,FRANCE
关键词
TOLBUTAMIDE; NMDA (N-METHYL-D-ASPARTATE); HIPPOCAMPUS;
D O I
10.1016/0014-2999(93)90529-Q
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of the hypoglycemic sulphonylurea tolbutamide, a marker of K+-ATP channels, on the N-methyl-D-aspartate-(NMDA) and kainate-activated currents were studied in rat hippocampal neurons in culture, using the patch-clamp technique in a whole-cell configuration. Tolbutamide (500 mu M) reversibly increased the peak amplitude and the steady state level of NMDA-but not kainate-evoked currents. This effect was not glycine dependent as it was observed at low and saturated concentrations of glycine. The affinity of the NMDA receptor-channel complex for glycine did not change in the presence of tolbutamide. The action of tolbutamide on the NMDA-activated current was not mediated by K+-ATP channels since CsCl was added intracellularly at concentrations which completely blocked all K+ channels. Possible mechanisms explaining the effect of tolbutamide via the modulation of intracellular messengers are discussed.
引用
收藏
页码:325 / 329
页数:5
相关论文
共 50 条
  • [31] CALCIUM INFLUX THROUGH N-METHYL-D-ASPARTATE CHANNELS ACTIVATES A POTASSIUM CURRENT IN POSTNATAL RAT HIPPOCAMPAL-NEURONS
    ZORUMSKI, CF
    THIO, LL
    CLARK, GD
    CLIFFORD, DB
    NEUROSCIENCE LETTERS, 1989, 99 (03) : 293 - 299
  • [32] Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro
    Arvanov, VL
    Liang, X
    Schwartz, J
    Grossman, S
    Wang, RY
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1997, 283 (01): : 226 - 234
  • [33] N-METHYL-D-ASPARTATE AND KAINATE RECEPTOR GENE-EXPRESSION IN HIPPOCAMPAL PYRAMIDAL AND GRANULAR NEURONS IN THE KINDLING MODEL OF EPILEPTOGENESIS
    KAMPHUIS, W
    HENDRIKSEN, H
    DIEGENBACH, PC
    DASILVA, FHL
    NEUROSCIENCE, 1995, 67 (03) : 551 - 559
  • [34] ONTOGENICALLY RELATED PROPERTIES OF N-METHYL-D-ASPARTATE RECEPTORS IN RAT HIPPOCAMPAL-NEURONS AND THE AGE-SPECIFIC SENSITIVITY OF DEVELOPING NEURONS TO LEAD
    ISHIHARA, K
    ALKONDON, M
    MONTES, JG
    ALBUQUERQUE, EX
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1995, 273 (03): : 1459 - 1470
  • [35] L-HOMOCYSTEATE PREFERENTIALLY ACTIVATES N-METHYL-D-ASPARTATE RECEPTORS TO CA1 RAT HIPPOCAMPAL-NEURONS
    PROVINI, L
    ITO, S
    BENARI, Y
    CHERUBINI, E
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1991, 3 (10) : 962 - 970
  • [36] EPILEPTIFORM BURSTS ELICITED IN CA3 HIPPOCAMPAL-NEURONS BY A VARIETY OF CONVULSANTS ARE NOT BLOCKED BY N-METHYL-D-ASPARTATE ANTAGONISTS
    NEUMAN, R
    CHERUBINI, E
    BENARI, Y
    BRAIN RESEARCH, 1988, 459 (02) : 265 - 274
  • [37] PROPOFOL PROTECTS CULTURED RAT HIPPOCAMPAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE TOXICITY
    HANS, P
    BONHOMME, V
    COLLETTE, J
    ALBERT, A
    MOONEN, G
    JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 1994, 6 (04) : 249 - 253
  • [38] Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons:: Absence of regional differences in sensitivity to ethanol
    Criswell, HE
    Ming, Z
    Griffith, BL
    Breese, GR
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 304 (01): : 192 - 199
  • [39] CONFOCAL MICROSCOPIC IMAGING OF [CA2+]I IN CULTURED RAT HIPPOCAMPAL-NEURONS FOLLOWING EXPOSURE TO N-METHYL-D-ASPARTATE
    SEGAL, M
    MANOR, D
    JOURNAL OF PHYSIOLOGY-LONDON, 1992, 448 : 655 - 676
  • [40] Secreted amyloid precursor protein α selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons:: Involvement of cyclic GMP
    Furukawa, K
    Mattson, MP
    NEUROSCIENCE, 1998, 83 (02) : 429 - 438