SYNTHESIS OF 11-ARYL-7,8,9,10-TETRAHYDRO-1,2,3-TRIAZINO-[4',5'-4,5]THIENO[2,3-B]CHINOLINES WITH ANTIANAPHYLACTIC ACTIVITY

被引：0

作者：

WAGNER, G ^{[1
]}

VIEWEG, H ^{[1
]}

LEISTNER, S ^{[1
]}

机构：

[1] UNIV LEIPZIG,FACHBEREICH BIOWISSENSCH,O-7010 LEIPZIG,GERMANY

来源：

PHARMAZIE | 1993年 / 48卷 / 08期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an antianaphylactic activity.

引用

页码：576 / 578

页数：3

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