SYNTHESIS OF 11-ARYL-7,8,9,10-TETRAHYDRO-1,2,3-TRIAZINO-[4',5'-4,5]THIENO[2,3-B]CHINOLINES WITH ANTIANAPHYLACTIC ACTIVITY

被引：0
|
作者：
WAGNER, G [1 ]
VIEWEG, H [1 ]
LEISTNER, S [1 ]
机构：
[1] UNIV LEIPZIG,FACHBEREICH BIOWISSENSCH,O-7010 LEIPZIG,GERMANY
来源：
PHARMAZIE | 1993年 / 48卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an antianaphylactic activity.
引用
收藏
页码：576 / 578
页数：3
相关论文
共 50 条
  • [1] SYNTHESIS OF 4-AMINOPYRIMIDO[4',5'-4,5]THIENO[2,3-B]QUINOLINES
    RAJ, TT
    AMBEKAR, SY
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1988, 33 (04): : 530 - 531
  • [2] Synthesis of 4-aminoderivatives of 7,8,9,10-tetrahydropyrimido[4′,5′:4,5]furo[2,3-b]quinoline
    Dabaeva, V. V.
    Bagdasaryan, M. R.
    Noravyan, A. S.
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2007, (10): : 1571 - 1573
  • [3] Synthesis and Neurotropic Activity of New Pyrimido[4′,5′:4,5]Thieno[2,3-b]Quinoline Derivatives
    V. V. Dabaeva
    M. R. Bagdasaryan
    A. S. Noravyan
    I. A. Dzhagatspanyan
    I. M. Nazaryan
    A. G. Akopyan
    Pharmaceutical Chemistry Journal, 2015, 49 : 587 - 591
  • [4] SYNTHESIS AND NEUROTROPIC ACTIVITY OF NEW PYRIMIDO[4′,5′:4,5]THIENO[2,3-b]QUINOLINE DERIVATIVES
    Dabaeva, V. V.
    Bagdasaryan, M. R.
    Noravyan, A. S.
    Dzhagatspanyan, I. A.
    Nazaryan, I. M.
    Akopyan, A. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (09) : 587 - 591
  • [5] A SYNTHESIS OF HETEROCYCLIC RING-SYSTEMS - PYRIDO[3',2'-4,5]THIENO[2,3-B]PYRROLIZINE AND PYRIDO[6',5'-4,5][3',2'-4,5]DITHIENO[2,3-B'-2,3-B]DIPYRROLIZINE
    PEINADOR, C
    VEIGA, C
    VILAR, J
    QUINTELA, JM
    HETEROCYCLES, 1994, 38 (06) : 1299 - 1305
  • [6] A convenient synthesis of dithieno[2,3-b] [2,3-h]quinolines and pyrimido [4′,5′:4,5]thieno [2,3-b]thieno[2,3-h]quinolines
    Geies, AA
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1999, 148 : 201 - 214
  • [7] Synthesis and antitumor activity of pyrano[4′,3′:4,5]pyrido[2, 3-b]thieno[3,2-d]-1,2,3-triazine and l,2,3-triazino[4′,5′:4, 5|thieno-[2,3-c]isoquinoline derivatives
    Paronikyan E.G.
    Noravyan A.S.
    Akopyan Sh.F.
    Arsenyan F.G.
    Stepanyan G.M.
    Garibdzhanyan B.T.
    Pharmaceutical Chemistry Journal, 2006, 40 (6) : 293 - 295
  • [8] Synthesis of thieno[2,3-b][1,6]naphthyridines and pyrimido[4′,5′:4,5] thieno[2,3-b][1,6]naphthyridines
    Abdel-Wadood, Fatma K.
    Abdel-Monem, Maisa I.
    Fahmy, Atiat M.
    Geies, Ahmed A.
    JOURNAL OF CHEMICAL RESEARCH, 2008, (02) : 89 - 94
  • [9] SYNTHESIS OF SOME NEW PYRIMIDO[4',5'-4,5]THIENO[2,3-B]QUINOLINE DERIVATIVES
    BAKHITE, EA
    ABBADY, MS
    RADWAN, SM
    COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1993, 58 (06) : 1457 - 1462
  • [10] DIMROTH REARRANGEMENT OF PYRIMIDO[4',5'-4,5]THIENO[2,3-B]QUINOLINES
    RAJ, TT
    AMBEKAR, SY
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1990, 67 (03) : 260 - 262
12345