ONSET AND DURATION OF HYPOALGESIA OF LIDOCAINE SPRAY APPLIED TO ORAL-MUCOSA - A DOSE-RESPONSE STUDY

被引:27
|
作者
SCHONEMANN, NK
VANDERBURGHT, M
ARENDTNIELSEN, L
BJERRING, P
机构
[1] UNIV HOSP AARHUS,DEPT ANAESTHESIOL,TAGE HANSENS GADE,DK-8000 AARHUS,DENMARK
[2] UNIV AALBORG,AALBORG,DENMARK
关键词
ANALGESIA; ARGON LASER; EXPERIMENTAL PAIN; LIDOCAINE; THRESHOLD; TOPICAL ANALGESIA;
D O I
10.1111/j.1399-6576.1992.tb03554.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Lidocaine is often used as a topical analgesic prior to painful procedures performed in the oral cavity and upper airways. In this study the optimal time inter-val for performance of painful procedures in the oral cavity and the upper airways was determined by spraying lidocaine solution on the mucous membranes of the mouth with subsequent measurements of pain thresholds induced by argon-laser stimulation. Two different dosages (30 mg and 60 mg) of lidocaine spray were administered to the oral mucosa of the lower lip in healthy volunteers. Repeated measurements were performed until normal sensitivity returned after 15 min. Pain thresholds increased 62% after 30 mg lidocaine and 50% after 60 mg lidocaine (a non-significant difference). Thus repeated applications were found to be without any additional hypoalgesic effect. Maximal hypoalgesia was reached after 4 to 5 min. Complete analgesia was not obtained. The hypoalgesic effect lasted until 14 min, but painful procedures should be performed in the time interval 3-8 min after application.
引用
收藏
页码:733 / 735
页数:3
相关论文
共 50 条
  • [31] Poor Uncorrected Visual Acuity and Association With Sleep Duration and Screen Time: A Dose-Response Relationship Study
    Hu, Yueyang
    Xu, Qiaoyi
    Shi, Jikang
    Lin, Xinli
    Fei, Junsong
    Hu, Yuanchao
    Mei, Songli
    Wu, Xiaogang
    DOSE-RESPONSE, 2021, 19 (04):
  • [32] Dose-response association of the duration and volume of physical activity with incident dementia: A cosmic collaborative cohort study
    Wu, Wanqing
    Ding, Ding
    Zhao, Qianhua
    Xiao, Zhenxu
    Ganguli, Mary
    Haan, Mary
    Lima-Costa, Maria Fernanda
    Castro-Costa, Erico
    Ng, Tze Pin
    Gureje, Oye
    Scarmeas, Nikolaos
    Brodaty, Henry
    Lipton, Richard
    Katz, Mindy
    Lipnicki, Darren
    Sachdev, Perminder
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2021, 429 : 109 - 109
  • [33] DIMINISHED BONE-RESORPTION IN RATS AFTER ORAL XYLITOL ADMINISTRATION - A DOSE-RESPONSE STUDY
    MATTILA, P
    SVANBERG, M
    KNUUTTILA, M
    CALCIFIED TISSUE INTERNATIONAL, 1995, 56 (03) : 232 - 235
  • [34] NO PROTECTION BY ORAL TERBUTALINE AGAINST EXERCISE-INDUCED ASTHMA IN CHILDREN - A DOSE-RESPONSE STUDY
    FUGLSANG, G
    HERTZ, B
    HOLM, EB
    EUROPEAN RESPIRATORY JOURNAL, 1993, 6 (04) : 527 - 530
  • [35] DOSE-RESPONSE STUDY OF ORAL FAMOTIDINE FOR REDUCTION OF GASTRIC-ACIDITY AND VOLUME IN OUTPATIENTS AND INPATIENTS
    TALKE, PO
    SOLANKI, DR
    ANESTHESIA AND ANALGESIA, 1993, 77 (06): : 1143 - 1148
  • [36] DOSE-RESPONSE AND PHARMACOKINETIC STUDY WITH ALMITRINE BISMESYLATE AFTER SINGLE ORAL ADMINISTRATIONS IN COPD PATIENTS
    BURY, T
    JEANNOT, JP
    ANSQUER, JC
    RADERMECKER, M
    EUROPEAN RESPIRATORY JOURNAL, 1989, 2 (01) : 49 - 55
  • [37] Regulation of Operant Oral Ethanol Self-Administration: A Dose-Response Curve Study in Rats
    Carnicella, Sebastien
    Yowell, Quinn V.
    Ron, Dorit
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2011, 35 (01) : 116 - 125
  • [38] The hypnotic and analgesic effects of oral clonidine during sevoflurane anesthesia in children: A dose-response study
    Inomata, S
    Kihara, S
    Miyabe, M
    Sumiya, K
    Baba, Y
    Kohda, Y
    Toyooka, H
    ANESTHESIA AND ANALGESIA, 2002, 94 (06): : 1479 - 1483
  • [39] ACUTE EFFECTS OF ORAL ALPRENOLOL ON EXERCISE TOLERANCE IN PATIENTS WITH ANGINA PECTORIS - DOSE-RESPONSE STUDY
    SEALEY, BJ
    LILJEDAL, J
    NYBERG, G
    ABLAD, B
    BRITISH HEART JOURNAL, 1971, 33 (04): : 481 - &
  • [40] ORAL ISOSORBIDE DINITRATE IN ANGINA-PECTORIS - COMPARISON OF DURATION OF ACTION AND DOSE-RESPONSE RELATION DURING ACUTE AND SUSTAINED THERAPY
    THADANI, U
    FUNG, HL
    DARKE, AC
    PARKER, JO
    CRUISE, MJ
    AMERICAN JOURNAL OF CARDIOLOGY, 1982, 49 (02): : 411 - 419