MEAN VOLUME OF PIGMENTED NEURONS IN THE SUBSTANTIA-NIGRA IN PARKINSONS-DISEASE

被引：14
|
作者：
MOLLER, A [1 ]
机构：
[1] AARHUS UNIV,HVIDOVRE HOSP,NEUROL RES LAB,STEREOL RES LAB,DK-8000 AARHUS,DENMARK
来源：
ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 85卷
关键词：
MEAN CELL VOLUME; PARKINSONS DISEASE; STEREOLOGY; SUBSTANTIA-NIGRA; ROTATOR;
D O I：
10.1111/j.1600-0404.1992.tb05036.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A new unbiased stereological estimator, the rotator, was used to estimate the mean volume of pigmented substantia nigra (SN) neurons in three Parkinson's disease (PD) brains and agematched controls. Average pigmented neuron volume was 31300-mu-m3 (5200) in controls and 28900-mu-m3 (120) in patients. Estimating the absolute size distribution, revealed that PD patients had almost-equal-to 80% less total SN pigmented volume than controls. Compared with biased methods, in addition to dramatic improvements in efficiency and accuracy. results obtained by the unbiased rotator suggest that primarily the largest pigmented neurons in SN are lost in PD.
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页码：37 / 39
页数：3
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