ASSIGNMENT OF THE PIG APOLIPOPROTEIN-B LOCUS (APO-B) TO CHROMOSOME REGION 3Q24-QTER

被引：0
|
作者：
SOLINAS, S
HASLERRAPACZ, J
MAEDA, N
RAPACZ, J
FRIES, R
机构：
[1] SWISS FED INST TECHNOL,INST NUTZTIERWISSENSCH,ZUCHTUNGSBIOL GRP,TANNENSTR 1,CH-8092 ZURICH,SWITZERLAND
[2] UNIV WISCONSIN,DEPT MEAT & ANIM SCI,MADISON,WI 53706
[3] UNIV N CAROLINA,DEPT PATHOL,CHAPEL HILL,NC 27514
[4] UNIV WISCONSIN,DEPT GENET,MADISON,WI 53706
来源：
ANIMAL GENETICS | 1992年 / 23卷 / 01期
关键词：
APOLIPOPROTEIN-B; SWINE; CHROMOSOME-3; GENE MAPPING;
D O I：
暂无
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
The locus for apolipoprotein-B (APOB) has been chromosomally assigned in swine by in situ hybridization of a genomic probe to metaphase chromosomes. As expected based on the observation of extensive linkage conservation and based on the previous assignment of the malate dehydrogenase locus (MDH1) in swine, APOB maps to chromosome 3, specifically to region 3q24-qter. Variations at APOB may represent both in humans and in swine risk factors for hypercholesterolaemia and atherosclerosis. Evidence presented here that the human and porcine APOB occupy evolutionarily conserved chromosome regions provides a basis for using the pig as an animal model to study the APOB associated atherosclerosis risk.
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页码：71 / 75
页数：5
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