PEPTIDE-T FROM HUMAN-IMMUNODEFICIENCY-VIRUS DOES NOT INTERACT WITH VIP RECEPTOR-EFFECTOR SYSTEM IN IMMUNOCOMPETENT CELLS OF RAT AND MOUSE

被引：1
|
作者：
POZO, D [1 ]
SEGURA, JJ [1 ]
GUERRERO, JM [1 ]
CALVO, JR [1 ]
机构：
[1] UNIV SEVILLE,SCH MED,DEPT MED BIOCHEM & MOLEC BIOL,E-41009 SEVILLE,SPAIN
来源：
BIOSCIENCE REPORTS | 1994年 / 14卷 / 05期
关键词：
VIP; IMMUNOCOMPETENT CELLS; HIV; PEPTIDE T;
D O I：
10.1007/BF01209730
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human immunodeficiency virus (HIV) infection is initiated by attachment of the virus to specific target cells. An octapeptide sequence contained within the envelope of HIV, peptide T, mediates the viral binding. Since there is an appreciable structural similarity between peptide T and an eight amino acid sequence of VIP, it is interesting to investigate the interaction of peptide T with the VIP receptor-effector system of immunocompetent cells from both rat and mouse. In this paper, we show the lack of interaction between peptide T and VIP receptor-effector system in peripheral blood lymphocytes, spleen lymphocytes and macrophages of rat and in macrophages of mouse. These results do not support the hypothesis that HIV through peptide T may interact with the VIP receptor-effector system present in immunocompetent cells.
引用
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页码：251 / 257
页数：7
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