INFLUENCE OF THIORPHAN AND PHOSPHORAMIDON ON THE RELAXANT EFFECT OF VASOACTIVE INTESTINAL POLYPEPTIDE AND NONADRENERGIC NONCHOLINERGIC NEURON STIMULATION IN THE RAT GASTRIC FUNDUS

被引：1
|
作者：
SMITS, GJ [1 ]
LEFEBVRE, RA [1 ]
机构：
[1] STATE UNIV GHENT,SCH MED,HEYMANS INST PHARMACOL,DE PINTELAAN 185,B-9000 GHENT,BELGIUM
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 200卷 / 2-3期
关键词：
GASTRIC FUNDUS (RAT); NONADRENERGIC; NONCHOLINERGIC; (NANC); NEUROTRANSMITTERS; VIP (VASOACTIVE INTESTINAL PEPTIDE); NEUTRAL ENDOPEPTIDASE; THIORPHAN; PHOSPHORAMIDON;
D O I：
10.1016/0014-2999(91)90597-J
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Relaxations were induced in longitudinal muscle strips of the rat gastric fundus by exogenous administration of vasoactive intestinal polypeptide (VIP) and by transmural stimulation in the presence of atropine. These responses were not influenced by two neutral endopeptidase inhibitors, thiorphan (3 x 10(-5) M) and phosphoramidon (10(-5) M). This suggests that neutral endopeptidase is not involved in the breakdown of exogenous VIP and non-adrenergic non-cholinergic inhibitory transmitters of the rat gastric fundus.
引用
收藏
页码：361 / 364
页数：4
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