RELEASE OF VASOACTIVE INTESTINAL POLYPEPTIDE FROM THE RAT GASTRIC FUNDUS

被引：44
|
作者：
DAMATO, M
CURRO, D
MONTUSCHI, P
CIABATTONI, G
RAGAZZONI, E
LEFEBVRE, RA
机构：
[1] UNIV CATTOLICA SACRO CUORE, SCH MED, DEPT PHARMACOL, L GO F VITO 1, I-00168 ROME, ITALY
[2] GENT MED SCH, HEYMANS INST PHARMACOL, B-9000 GHENT, BELGIUM
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 105卷 / 03期
关键词：
STOMACH (RAT); NONADRENERGIC NONCHOLINERGIC (NANC) NEURONS; RELAXATION; VASOACTIVE INTESTINAL POLYPEPTIDE (VIP); PEPTIDE HISTIDINE ISOLEUCINAMIDE (PHI);
D O I：
10.1111/j.1476-5381.1992.tb09040.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1 Auxotonic responses and release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) induced by electrical field stimulation (EFS) were studied in longitudinal muscle strips from the gastric fundus of reserpinized rats suspended between parallel platinum electrodes in Krebs solution containing atropine (1-mu-M), 5-hydroxytryptamine (3-mu-M) and bovine serum albumin (50 mgl-1). 2 EFS (supramaximal voltage, 1 ms, 0.25-32.0 Hz, trains of 2 min) induced frequency-dependent relaxations. 3 EFS at frequencies greater-than-or-equal-to 8 Hz also produced significant increases in VIP-LI release. 4 VIP-LI release induced by EFS at 16 Hz no longer occurred in the presence of tetrodotoxin (1-mu-M) or a Ca2+ -free medium. 5 Detection of VIP-LI upon activation of inhibitory non-adrenergic, non-cholinergic neurones indicates that VIP meets the 'detectable release' criterion for an inhibitory neurotransmitter in the rat gastric fundus.
引用
收藏
页码：691 / 695
页数：5
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