SYNERGISTIC EFFECT OF RETINOIC ACID AND 1,25-DIHYDROXYVITAMIN-D3 ON THE DIFFERENTIATION OF THE HUMAN MONOCYTIC CELL LINE-U937

被引：75
|
作者：
TAIMI, M [1 ]
CHATEAU, MT [1 ]
CABANE, S [1 ]
MARTI, J [1 ]
机构：
[1] UNIV MONTPELLIER 1,FAC PHARM,F-34060 MONTPELLIER,FRANCE
来源：
LEUKEMIA RESEARCH | 1991年 / 15卷 / 12期
关键词：
U937; HL-60; RETINOIC ACID; 1,25-DIHYDROXYVITAMIN-D3; DIFFERENTIATION;
D O I：
10.1016/0145-2126(91)90183-T
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The human-derived leukemia cell lines HL-60 and U937 are known to differentiate into more mature phagocytic cells in the presence of retinoic acid or 1,25-dihydroxyvitamin D3. We studied the effects of combinations of these two agents on cell growth and differentiation. These treatments were found to increase inhibition of cell proliferation. A dramatic enhancement of functional properties was observed in U937, but not HL-60 cells exposed to combinations of the two inducers. We investigated the conditions required to obtain the highest synergistic effects on the differentiation of U937 cells. These effects were found to be highly dose-dependent. We found that synergism required the simultaneous presence of both inducers and did not occur upon sequential exposure to each agent used separately.
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页码：1145 / 1152
页数：8
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