TISSUE REACTION ON PLLA VERSUS STAINLESS-STEEL INTERLOCKING NAILS FOR FRACTURE FIXATION - AN ANIMAL STUDY

被引：31
|
作者：
VANDERELST, M
DIJKEMA, ARA
KLEIN, CPAT
PATKA, P
HAARMAN, HJTM
机构：
[1] LEIDEN UNIV,BIOMAT RES GRP,LEIDEN,NETHERLANDS
[2] ACTA,AMSTERDAM,NETHERLANDS
来源：
BIOMATERIALS | 1995年 / 16卷 / 02期
关键词：
POLYLACTIC ACID; BIODEGRADATION; FRACTURE HEALING; TISSUE REACTION;
D O I：
10.1016/0142-9612(95)98270-O
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In order to develop a biodegradable interlocking nail for fracture fixation, polylactic acid (PLLA) rods were implanted in the femoral bone of young pigs. A midshaft osteotomy was performed in order to mimic a fracture. The tissue response to PLLA rods versus stainless steel rods was studied after 1 and 3 months of implantation. Fracture-healing characteristics and chemical and mechanical properties of the PLLA rods were studied after explantation. Mechanical properties deteriorated during implantation and chemical properties changed significantly in 1 and 3 months of implantation. PLLA and stainless steel induced a similar tissue reaction during the studied implantation time of 3 months.
引用
收藏
页码：103 / 106
页数：4
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