3 MONOCLONAL IGG COMPONENTS, AN IGG4(LAMBDA), AN IGG2(KAPPA) AND AN IGG1/IGG3-(KAPPA) GM(F,B) HYBRID, IN A SINGLE MYELOMA PATIENT

被引：0
|
作者：
MILOSEVICJOVCIC, N
DOVEZENSKI, N
JOVANOVIC, L
ROLOVIC, Z
GOTIC, M
RADOSEVIC, N
SUVAJDZIC, N
TOSIC, L
机构：
[1] UNIV BELGRADE, SCH MED, INST MED RES, YU-11001 BELGRADE, YUGOSLAVIA
[2] UNIV BELGRADE, SCH MED, INST HAEMATOL, BELGRADE, YUGOSLAVIA
来源：
EUROPEAN JOURNAL OF HAEMATOLOGY | 1995年 / 54卷 / 05期
关键词：
TRICLONAL GAMMOPATHY; IGG SUBCLASS; ALLOTYPE; IDIOTYPE; HYBRID;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
An unusual triclonal Ige combination in the serum of a 56-year old male with clinical stage IIIB multiple myeloma is reported. The patient initially had an lgG4(lambda) monoclonal protein in his serum and later developed an IgG2(kappa) and an IgG (kappa) which possessed the characteristics of both IgG1 and IgG3 subclasses with an unusual combination of allotypic markers. Three M-proteins did not share idiotypic determinants. A rare class-switch recombination followed by mutation has been considered as a possible mechanism leading to this combination.
引用
收藏
页码：288 / 295
页数：8
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