IDENTIFICATION AND CHARACTERIZATION OF PARATHYROID-HORMONE PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR IN CULTURED ASTROCYTES

被引：27
|
作者：
HASHIMOTO, H [1 ]
AINO, H [1 ]
OGAWA, N [1 ]
NAGATA, S [1 ]
BABA, A [1 ]
机构：
[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,SUITA,OSAKA 565,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.1555
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH[1-34], stimulated adenylate cyclase with the EC(50) value of 3 nM, but not phospholipase C. PTH[1-34] changed the morphology of protoplasmic type astrocytes into process-bearing ones. Thus, type I astrocytes possess PTH/PTHrP receptor that is coupled to an adenylate cyclase-activating system but not to phospholipase C. (C) 1994 Academic Press, Inc.
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页码：1042 / 1048
页数：7
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