THE ADENOMATOUS POLYPOSIS-COLI GENE AND HUMAN CANCERS

被引：19
|
作者：
NAKAMURA, Y
机构：
[1] Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, 108, 4-6-1, Shirokanedai, Minato-ku
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1995年 / 121卷 / 9-10期
关键词：
ADENOMATOUS POLYPOSIS COLI GENE; CANCER;
D O I：
10.1007/BF01197765
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The APC (adenomatous polyposis coli) gene was isolated as a gene responsible for familial polyposis coli, an autosomal-dominant disease, characterized by development of hundreds to thousands of adenomatous polyps in the colon and rectum. However, recent studies revealed that inactivation of the APC gene also plays a significant role in development of sporadic forms of colorectal adenoma and carcinoma. Furthermore, somatic mutations have also been detected in pancreatic carcinomas as well as some type of gastric carcinomas, suggesting that APC has a critical function in regulation of cell growth in digestive tissues.
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页码：529 / 534
页数：6
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