HOST-REACTION AGAINST EMPTY ALGINATE-POLYLYSINE MICROCAPSULES - INFLUENCE OF PREPARATION PROCEDURE

被引：52
|
作者：
VANDENBOSSCHE, GMR
BRACKE, ME
CUVELIER, CA
BORTIER, HE
MAREEL, MM
REMON, JP
机构：
[1] STATE UNIV GHENT,PHARMACEUT TECHNOL LAB,HARELBEKESTR 72,B-9000 GHENT,BELGIUM
[2] STATE UNIV GHENT,EXPTL CANCEROL LAB,B-9000 GHENT,BELGIUM
[3] STATE UNIV GHENT,DEPT PATHOL,B-9000 GHENT,BELGIUM
[4] STATE UNIV GHENT,EMBRYOL LAB,B-9000 GHENT,BELGIUM
[5] STATE UNIV GHENT HOSP,B-9000 GHENT,BELGIUM
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 02期
关键词：
D O I：
10.1111/j.2042-7158.1993.tb03694.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Microcapsules, prepared with alginate and polylysine, were injected intraperitoneally into mice and the number of peritoneal leucocytes as well as the cells sticking to the capsule wall were counted after 4-28 days. A significant increase in host reaction was observed when the microcapsules contained an outer layer of polylysine as compared with calcium alginate beads without polylysine or microcapsules coated with an outer layer of alginate. The alginate sources influenced the host reaction significantly. After an intraperitoneal residence of 4 days, the microcapsules were mainly surrounded by macrophages. After 28 days, several cell layers surrounded the microcapsules; macrophages, multinucleate giant cells, fibroblasts and mesothelial cells.
引用
收藏
页码：115 / 120
页数：6
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