SHORT-CIRCUIT CURRENT RESPONSES TO 5-HYDROXYTRYPTAMINE IN HUMAN ILEAL MUCOSA ARE MEDIATED BY A 5-HT(4) RECEPTOR

被引：45
|
作者：
BURLEIGH, DE
BORMAN, RA
机构：
[1] Department of Pharmacology, Queen Mary and Westfield College, London
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 241卷 / 01期
关键词：
5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); MUCOSA; ION TRANSPORT; ILEUM; (HUMAN);
D O I：
10.1016/0014-2999(93)90943-C
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
5-Hydroxytryptamine (5-HT) increases short-circuit current when added to the serosal side of human isolated ileal mucosa; mucosally applied 5-HT was ineffective. Tetrodotoxin reduced both basal short-circuit current and increases in short-circuit current due to electrical field stimulation of mucosal nerves. However, neither tetrodotoxin, ondansetron nor methysergide plus ketanserin affected 5-HT induced increases in short-circuit current. Application of SDZ 205-557 (2-diethylaminoethyl-(2-methoxy-4-amino-5-chloro) benzoate) to the tissue caused a significant increase in the concentration ratio between two successive 5-HT response curves. It is concluded that the effect of 5-HT on short-circuit current of human ileal mucosa appears to be due to stimulation of a 5-HT4 receptor.
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页码：125 / 128
页数：4
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