3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .8. N-SUBSTITUTED 3-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMIDES, N-SUBSTITUTED 3-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMINES AND 2-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)ETHANAMINES WITH PLATELET ANTIAGGREGATING, HYPOTENSIVE, ANTIARRHYTHMIC AND OTHER ACTIVITIES

被引：0
|
作者：
BRUNO, O
BONDAVALLI, F
RANISE, A
SCHENONE, P
CENICOLA, ML
DONNOLI, D
FILIPPELLI, W
LOSASSO, C
COSTANTINO, M
MARMO, E
机构：
[1] UNIV GENOA,IST SCI FARMACEUT,VIALE BENEDETTO XV 3,I-16132 GENOA,ITALY
[2] UNIV FEDERICO II,FAC MED & CHIRURG,IST FARMACOL & TOSSICOL,I-80138 NAPLES,ITALY
来源：
FARMACO | 1991年 / 46卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The synthesis of N,N-disubstituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides and -propanamines, starting from 4-benzoyloxy-3,5-diphenyl-1H-pyrazole, and of N-substituted 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines, starting from 4-acetoxy-1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole, is described. Some of the above compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as moderate hypotensive, antiarrhythmic, local anesthetic, sedative and antiinflammatory activities in rats and mice.
引用
收藏
页码：477 / 499
页数：23
相关论文
共 50 条
  • [41] (3,6-dichloropyridin-2-yl)(3,5-dimethyl-1H-pyrazol-1-yl)methanone
    Zhuang, Yue
    Zhang, Shan-Shan
    Yin, Xian-Hong
    Zhao, Kai
    Lin, Cui-Wu
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1224 - U1521
  • [42] 2-(3,5-Dimethyl-1H-pyrazol-1-yl)thiazolo[4,5-b]pyridine
    Lan, Honghong
    Zheng, Min
    Wang, Ye
    MOLBANK, 2019, 2019 (03)
  • [43] Diethyl 2-[(3,5-dimethyl-1H-pyrazol-1-yl)(4-methoxyphenyl)methyl]propanedioate
    Meskini, Ihssan
    Daoudi, Maria
    Daran, Jean-Claude
    Kerbal, Abdelali
    Zouihri, Hafid
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1965 - U736
  • [44] Green and efficient synthesis of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-phenylquinazolin-4-amines
    Reddy, Chittireddy Venkata Ramana
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [45] Two N-substituted 3,5-diphenyl-2-pyrazoline-1-thiocarboxamides
    Köysal, Y
    Isik, S
    Sahin, G
    Palaska, E
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2005, 61 : O542 - O544
  • [46] 4-(3,5-Dimethyl-1H-pyrazol-1-yl)phthalazin-1(2H)-one monohydrate
    Kai, Zhao
    Yin, Xian-Hong
    Yu, Feng
    Jie, Zhu
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O4618 - U4224
  • [47] 3-(3-Chloroanilino)-1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one
    Saeed, Aamer
    Hussain, Shahid
    Bolte, Michael
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1231 - U1413
  • [48] Microwave Assisted Synthesis of 1-[5-(Substituted Aryl)-1H-Pyrazol-3-yl]3,5-Diphenyl-1H-1,2,4-Triazole as Antinociceptive and Antimicrobial Agents
    Khanage, Shantaram Gajanan
    Mohite, Popat Baban
    Pandhare, Ramdas Bhanudas
    Raju, S. Appala
    ADVANCED PHARMACEUTICAL BULLETIN, 2014, 4 (02) : 105 - 112
  • [49] A tris(pyrazol-1-yl)methane bearing carboxylic acid groups at position 4:{1-[bis(4-carboxy-3,5-dimethyl-1H-pyrazol-1-yl)methyl]-3,5-dimethyl-1H-pyrazole-4-carboxylato}sodium dihydrate
    Alkorta, Ibon
    Elguero, Jose
    Angeles Garcia, Maria
    Lopez, Concepcion
    Claramunt, Rosa M.
    Andrade, Gabriel A.
    Yap, Glenn P. A.
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2013, 69 : 972 - 976
  • [50] Dichlorido(3,5-dimethyl-1H-pyrazole)[(3,5-dimethyl-1H-pyrazol-1-yl)(o-tolyl) methanone] palladium(II)
    Nelana, Simphiwe M.
    Kruger, Gert J.
    Darkwa, James
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : M206 - U1997
12345