EPR SPECTROSCOPIC STUDIES OF HEMOGLOBIN BREAKDOWN IN MALARIAL PARASITE-INFECTED ERYTHROCYTES

被引：5

作者：

CAMMACK, R ^{[1
]}

PATIL, DS ^{[1
]}

LINSTEAD, D ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT CELL BIOL,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS | 1994年 / 90卷 / 22期

关键词：

D O I：

10.1039/ft9949003409

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

EPR spectra of an insoluble fraction from the rodent malarial parasite Plasmodium berghei, grown in mouse erythrocytes, have been measured. Signals due to high-spin iron(III) haem and two low-spin haem species were detected. Comparison with other derivatives of haemoglobin, and the use of a simple ligand-field model, identified the low-spin species as imidazole-hydroxy and bis-imidazole derivatives of haem. These species may represent intermediate stages in the breakdown of haemoglobin to the insoluble form, haemozoin. The utility of EPR spectroscopy for the study of the breakdown pathway is discussed.

引用

页码：3409 / 3410

页数：2

共 37 条

[21] Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1
Dorin-Semblat, Dominique
Demarta-Gatsi, Claudia
Hamelin, Romain
Armand, Florence
Carvalho, Teresa Gil
Moniatte, Marc
Doerig, Christian
PLOS ONE, 2015, 10 (12):
[22] Evidence for a role for a Plasmodium falciparum homologue of Sec31p in the export of proteins to the surface of malaria parasite-infected erythrocytes
Adisa, A
Albano, FR
Reeder, J
Foley, M
Tilley, L
JOURNAL OF CELL SCIENCE, 2001, 114 (18) : 3377 - 3386
[23] ANTIBODIES IN MALARIAL SERA TO PARASITE ANTIGENS IN THE MEMBRANE OF ERYTHROCYTES INFECTED WITH EARLY ASEXUAL STAGES OF PLASMODIUM-FALCIPARUM
PERLMANN, H
BERZINS, K
WAHLGREN, M
CARLSSON, J
BJORKMAN, A
PATARROYO, ME
PERLMANN, P
JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 159 (06): : 1686 - 1704
[24] ISOLATION AND CHARACTERIZATION OF THE PLASMA-MEMBRANE OF HUMAN-ERYTHROCYTES INFECTED WITH THE MALARIAL PARASITE PLASMODIUM-FALCIPARUM
GRUENBERG, J
SHERMAN, IW
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (04): : 1087 - 1091
[25] STUDIES OF FOLIC AND FOLINIC ACID ACTIVITIES IN MONKEYS INFECTED WITH A MALARIAL PARASITE PLASMODIUM KNOWLESI
SIDDIQUI, WA
MEAGHER, MJ
SCHNELL, JV
GEIMAN, QM
FEDERATION PROCEEDINGS, 1966, 25 (2P1) : 540 - &
[26] Serological Conservation of Parasite-Infected Erythrocytes Predicts Plasmodium falciparum Erythrocyte Membrane Protein 1 Gene Expression but Not Severity of Childhood Malaria
Warimwe, George M.
Abdi, Abdirahman I.
Muthui, Michelle
Fegan, Gregory
Musyoki, Jennifer N.
Marsh, Kevin
Bull, Peter C.
INFECTION AND IMMUNITY, 2016, 84 (05) : 1331 - 1335
[27] Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes
Kriek, N
Tilley, L
Horrocks, P
Pinches, R
Elford, BC
Ferguson, DJP
Lingelbach, K
Newbold, CI
MOLECULAR MICROBIOLOGY, 2003, 50 (04) : 1215 - 1227
[28] IMMUNOFLUORESCENCE STUDIES ON ERYTHROCYTIC AND SPOROGONIC STAGES OF MALARIA PARASITE - STIPPLING IN INFECTED ERYTHROCYTES
ELNAHAL, HMS
BULLETIN OF THE WORLD HEALTH ORGANIZATION, 1969, 40 (01) : 158 - &
[29] POLYAMINE LEVELS AND THE ACTIVITY OF THEIR BIOSYNTHETIC-ENZYMES IN HUMAN-ERYTHROCYTES INFECTED WITH THE MALARIAL PARASITE, PLASMODIUM-FALCIPARUM
ASSARAF, YG
GOLENSER, J
SPIRA, DT
BACHRACH, U
BIOCHEMICAL JOURNAL, 1984, 222 (03) : 815 - 819
[30] FREE AMINO-ACIDS OF BLOOD PLASMA AND ERYTHROCYTES OF NORMAL DUCKS AND DUCKS INFECTED WITH MALARIAL PARASITE PLASMODIUM IOPHURAE
SIDDIQUI, WA
TRAGER, W
NATURE, 1967, 214 (5092) : 1046 - &

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