COCAINE CONDITIONED PLACE PREFERENCE IS ATTENUATED BY CHRONIC BUPRENORPHINE TREATMENT

被引：40
|
作者：
KOSTEN, TA [1 ]
MARBY, DW [1 ]
NESTLER, EJ [1 ]
机构：
[1] YALE UNIV, SCH MED, DEPT PSYCHIAT, MOLEC PSYCHIAT LAB, NEW HAVEN, CT 06519 USA
来源：
LIFE SCIENCES | 1991年 / 49卷 / 24期
关键词：
D O I：
10.1016/0024-3205(91)90490-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Previous research shows that buprenorphine (BUP), a mixed opioid agonist-antagonist, reduces cocaine use in humans and suppresses cocaine self-administration in monkeys. The present study found that BUP reduces cocaine's ability to condition a place preference in rats. Compared to vehicle treated rats, rats treated with BUP 2 times/day for 2 weeks spent significantly less time in the cocaine conditioned place compared to their respective saline trained controls. No conditioned place preference was shown for BUP alone. These results further implicate a role for the opioid system in cocaine use and stress the importance of differentiating chronic vs. acute opioid effects.
引用
收藏
页码：PL201 / PL206
页数：6
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