TNF ALPHA-INDUCED EXPRESSION OF ENDOTHELIAL ADHESION MOLECULES, ICAM-1 AND VCAM-1, IS LINKED TO PROTEIN-KINASE-C ACTIVATION

被引：89
|
作者：
MATTILA, P [1 ]
MAJURI, ML [1 ]
MATTILA, PS [1 ]
RENKONEN, R [1 ]
机构：
[1] UNIV HELSINKI,DEPT BACTERIOL,HAARTMANINKATU 3,SF-00290 HELSINKI 29,FINLAND
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1992年 / 36卷 / 02期
关键词：
D O I：
10.1111/j.1365-3083.1992.tb03087.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of protein kinase C (PKC) in TNF-alpha-induced activation of endothelial adhesion molecules ICAM-1 and VCAM-1 was analysed. Phorbol myristate acetate, which is known to activate PKC, was able to mimic TNF-alpha-induced up-regulation of ICAM-1 and partly also VCAM-1 expression. Similarly a PKC inhibitor, H7, but not another kinase inhibitor, HA1004, inhibited TNF-alpha-induced enhancement of ICAM-1 expression at both the mRNA and the protein level. Moreover we were able to measure a transient PKC activation peak at 16 min after TNF-alpha-induction in endothelial cells analysed by phorbol-dibutyrate binding. These results indicate that the TNF-alpha-induced effect on the regulation of endothelial adhesion molecule expression is at least partly mediated by PKC activation.
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收藏
页码：159 / 165
页数：7
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