Relationship of Polymorphism of Adhesion Molecules VCAM-1 and ICAM-1 with Preeclampsia

Objective. To investigate the relationship of polymorphism in vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) with preeclampsia (PE). Methods. The present study included 252 patients with PE and 200 healthy pregnant women as control admitted to our hospital from February 2012 to December 2016. Allelic discrimination of the rs5498 polymorphisms from the ICAM-1 gene and rs3181092 from the VCAM-1 gene was assessed using the TaqMan assay. Data was analyzed using SPSS 18.0. Results. In PE patients, both ratios of AA and AA+AG genotypes of VCAM-1 were significantly higher than those in the control group, P<0.05. The comparison of genotypes between PE patients with early-onset and late-onset showed that late-onset PE patients had a higher ratio of AA genotype in VCAM-1, P<0.05. Similarly, the ratio of genotype AA in severe PE was significantly higher than that in mild PE patients, P<0.05. However, the distribution of rs5498 polymorphism for ICAM-1 showed no significant difference in the groups. Conclusion. Rs3181092 polymorphism of VCAM-1 was associated with occurrence of PE, especially for late-onset and severe PE. However, whether rs5498 polymorphism of ICAM-lwas associated with PE needs more investigation.