MONOCLONAL-ANTIBODIES IPO-38 RECOGNIZING THE NUCLEAR ANTIGEN OF PROLIFERATING CELLS

被引：0
|
作者：
SIDORENKO, SP [1 ]
SHLAPATSKAYA, LN [1 ]
VETROVA, EP [1 ]
BERDOVA, AG [1 ]
YURCHENKO, OV [1 ]
KLENOVA, TT [1 ]
MIKHALAP, SV [1 ]
ABRAMENKO, IV [1 ]
GLUZMAN, DF [1 ]
机构：
[1] NATL ACAD SCI UKRAINE,RE KAVETSKY INST EXPTL PATHOL ONCOL & RADIOBIOL,KIEV 252022,UKRAINE
来源：
EKSPERIMENTALNAYA ONKOLOGIYA | 1994年 / 16卷 / 2-3期
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D O I：
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Monoclonal antibodies (mAb) IPO-38 of IgM isotype were generated after fusions of 653.A mouse myeloma cell line with spleen cells from BALB/c mice previously immunized by spleen cells from the patient with hairy cell leukemia. The reactivity of mAb IPO-38 was studied by indirect immunofluorescence technique on 11 cell lines, blood cells of 5 healthy persons and 57 patients with leukemias and malignant lymphomas. Tissue localizations of antigen was demonstrated with immunohistochemical PAP method. MFb IPO-38 were found to be directed against nuclear antigen of proliferating cells. This antigen is not expressed in quiescent and non-proliferating cells.
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页码：145 / 149
页数：5
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