PATHOLOGICAL-CHANGES IN EXPERIMENTALLY INDUCED HYPOCALCEMIA HYPOMAGNESEMIA IN GOATS

Experimental production of chronic hypocalcaemia in goats by slow gravity infusion of 1 to 2% Na2 EDTA daily for 90 days until the development of clinical hypocalcaemic state was associated with varying degrees of congestion and degeneration in kidneys, brain, heart, liver, lungs, thyroid and adrenals. Notable findings were the congestion of intertubular blood vessels both in cortex and medulla, and varying degrees of degenerative necrotic changes in the tubules and glomeruli of kidneys. Induction of clinical hypomagnesemia in goats with intraruminal administration of potassium chloride and citric acid @ 1.39 and 1.19 g/kg body weight, respectively, for 16 days was associated with significant pathomorphological changes comprising varying degrees of congestion in liver, kidneys, intestines and thyroid gland; mild to moderate parenchymatous degeneration and fatty changes of hepatocytes and degeneration of the tubular lining epithelium of kidneys.