DYSPROSIUM (DY-165) HYDROXIDE MACROAGGREGATES FOR RADIATION SYNOVECTOMY - ANIMAL STUDIES

被引：10

作者：

MCLAREN, A ^{[1
]}

HETHERINGTON, E ^{[1
]}

MADDALENA, D ^{[1
]}

SNOWDON, G ^{[1
]}

机构：

[1] AUSTRALIAN NUCL SCI & TECHNOL ORG, NEW ILLAWARRA RD, SUTHERLAND, NSW 2234, AUSTRALIA

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1990年 / 16卷 / 8-10期

关键词：

!sup]165[!/sup]Dy; Biodistribution in rats and rabbits; Dysprosium hydroxide macroaggregates; Preparation; Radiation synovectomy; Toxicity;

D O I：

10.1007/BF00998160

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This paper reports the development of a new chemical formulation, Dy-HMA, to utilise the advantages of dysprosium 165 in radiation synovectomy of certain forms of arthritis. Dy-HMA is a sterile suspension of dysprosium hydroxide macroaggregates (approximately 6 mg Dy/ml) in saline with the majority of particles in the 3-5 μm range. The absence of ferric hydroxide and a higher concentration of dysprosium in the formulation offer advantages over dysprosium ferric hydroxide macroaggregates, Dy-165-FHMA. Biodistribution studies in rats and rabbits with Dy-HMA show less leakage than with Dy-FHMA and considerably less leakage than with yttrium silicate colloid. Rabbits treated with intraarticular injections of Dy-HMA equivalent to 10-30 times the typical clinical dose showed no signs of any toxic effects. © 1990 Springer-Verlag.

引用

页码：627 / 632

页数：6