THE SYNTHESIS OF A CONFORMATIONALLY RIGID CALCIUM-CHANNEL BLOCKER

被引：4
|
作者：
BARRISH, JC [1 ]
SPERGEL, SH [1 ]
MORELAND, S [1 ]
HEDBERG, SA [1 ]
机构：
[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT PHARMACOL,PRINCETON,NJ 08543
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(00)80664-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The preparation of (+/-)-3 and 4, conformationally rigid calcium channel blockers related to diltiazem, is described starting from the known bicyclic ketone 5. The syntheses include the addition of an aryl organometallic reagent to the ketones 9 and 13a respectively, which occurs with unexpected pi-facial selectivity.
引用
收藏
页码：95 / 98
页数：4
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