EXPRESSION OF MAGE GENES IN PRIMARY AND METASTATIC CUTANEOUS MELANOMA

被引：267

作者：

BRASSEUR, F

RIMOLDI, D

LIENARD, D

LETHE, B

CARREL, S

ARIENTI, F

SUTER, L

VANWIJCK, R

BOURLOND, A

HUMBLET, Y

VACCA, A

CONESE, M

LAHAYE, T

DEGIOVANNI, G

DERAEMAECKER, R

BEAUDUIN, M

SASTRE, X

SALAMON, E

DRENO, B

JAGER, E

KNUTH, A

CHEVREAU, C

SUCIU, S

LACHAPELLE, JM

POUILLART, P

PARMIANI, G

LEJEUNE, F

CEROTTINI, JC

BOON, T

MARCHAND, M

机构：

[1] UNIV CATHOLIQUE LOUVAIN, CELLULAR GENET UNIT, BRUSSELS, BELGIUM

[2] UNIV LAUSANNE, LUDWIG INST CANC RES, LAUSANNE BRANCH, EPALINGES, SWITZERLAND

[3] CHU VAUDOIS, CTR PLURIDISCIPLINAIRE ONCOL, LAUSANNE, SWITZERLAND

[4] IST NAZL STUDIO & CURA TUMORI, DIV EXPTL ONCOL D, MILAN, ITALY

[5] FACHKLIN HORNHEIDE, MUNSTER, GERMANY

[6] UNIV CATHOLIQUE LOUVAIN, CLIN UNIV ST LUC, SERV CHIRURG PLAST, BRUSSELS, BELGIUM

[7] UNIV CATHOLIQUE LOUVAIN, CLIN UNIV ST LUC, SERV DERMATOL, BRUSSELS, BELGIUM

[8] UNIV CATHOLIQUE LOUVAIN, CLIN UNIV ST LUC, UNITE ONCOL, BRUSSELS, BELGIUM

[9] Univ Bari, DIMO, BARI, ITALY

[10] UNIV LIEGE, CHIRURG EXPTL LAB, SART, BELGIUM

[11] FREE UNIV BRUSSELS, INST JULES BORDET, BRUSSELS, BELGIUM

[12] INST CURIE, MED ONCOL SERV, PARIS, FRANCE

[13] HOP JOLIMONT, SERV ONCOL, HAINE ST PAUL, BELGIUM

[14] INST CURIE, ANAT PATHOL LAB, PARIS, FRANCE

[15] CLIN ST ELIZABETH, SERV ONCOL, NAMUR, BELGIUM

[16] CHU NANTES, DERMATOL CLIN, NANTES, FRANCE

[17] UNIV FRANKFURT, AKAD LEHRKRANKENHAUS, KRANKENHAUS NORDWEST, FRANKFURT, GERMANY

[18] CTR RECH & TRAITEMENTS CANCEROL CLAUDIUS REGAUD, TOULOUSE, FRANCE

[19] EORTC DATA CTR, BRUSSELS, BELGIUM

来源：

INTERNATIONAL JOURNAL OF CANCER | 1995年 / 63卷 / 03期

关键词：

D O I：

10.1002/ijc.2910630313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human genes MAGE-1 and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-1 and MAGE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3. We have analyzed the expression of these 4 MAGE genes in cutaneous melanoma. Sixteen of 100 primary tumors vs. 69 (48%) of 145 metastases from individual patients expressed MAGE-1. Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MAGE-2, MAGE-3, and MAGE-4. MAGE expression in primary tumors was correlated with tumor thickness: there was a significantly increased frequency in the expression of MAGE-1, -2 and -3 in tumors of greater thickness. Benign and dysplastic nevi, as well as in site melanomas, did not express any of the 4 MAGE genes. (C) 1995 Wiley-Liss, Inc.

引用

页码：375 / 380

页数：6

共 50 条

[31] Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma
Hugdahl, Emilia
Kalvenes, May Britt
Mannelqvist, Monica
Ladstein, Rita G.
Akslen, Lars A.
BRITISH JOURNAL OF CANCER, 2018, 118 (01) : 98 - 105
[32] MAGE expression in ocular melanomas during progression from primary to metastatic disease
Chen, PW
Murray, TG
Ksander, BR
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1997, 38 (04) : 2163 - 2163
[33] Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma
Emilia Hugdahl
May Britt Kalvenes
Monica Mannelqvist
Rita G Ladstein
Lars A Akslen
British Journal of Cancer, 2018, 118 : 98 - 105
[34] Expression of MAGE-A and NY-ESO-1 in Primary and Metastatic Cancers
Park, Tristen S.
Groh, Eric M.
Patel, Krishna
Kerkar, Sid P.
Lee, Chyi-Chia Richard
Rosenberg, Steven A.
JOURNAL OF IMMUNOTHERAPY, 2016, 39 (01) : 1 - 7
[35] P53 EXPRESSION IN CUTANEOUS MALIGNANT-MELANOMA - AN IMMUNOHISTOCHEMICAL STUDY OF 87 CASES OF PRIMARY, RECURRENT, AND METASTATIC MELANOMA
BARNHILL, RL
CASTRESANA, JS
RUBIO, MP
MARTIN, MT
IDOATE, M
VAZQUEZ, JJ
THOR, AD
MODERN PATHOLOGY, 1994, 7 (05) : 533 - 535
[36] High throughput expression studies in primary cutaneous melanoma
Spatz, Alan
PIGMENT CELL & MELANOMA RESEARCH, 2008, 21 (02) : 280 - 280
[37] High throughput expression studies in primary cutaneous melanoma
Spatz, A.
EJC SUPPLEMENTS, 2007, 5 (08): : 16 - 16
[38] Expression of MAGE, gp100 and tyrosinase genes in uveal melanoma cell lines
Luyten, GPM
van der Spek, CW
Brand, I
Sintnicolaas, K
de Waard-Siebinga, I
Jager, MJ
de Jong, PTVM
Schrier, PI
Luider, TM
MELANOMA RESEARCH, 1998, 8 (01) : 11 - 16
[39] Gene expression profiling of primary cutaneous melanoma: Expression of replication origins firing genes predicts clinical outcome.
Spatz, A.
Winnepenninckx, V.
Lazar, V.
Michiels, S.
Dessen, P.
Stas, M.
Eggermont, A. M.
Sarasin, A.
Tursz, T.
Van den Oord, J.
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (18) : 458S - 458S
[40] Metastatic Melanoma With Features of Desmoplastic Melanoma in a Patient With Primary Cutaneous Superficial Spreading Melanoma With Epithelioid Features
Modi, Mitul B.
Moshiri, Ata S.
Klein, Walter M.
Karakousis, Giorgos
Shafique, Khurram
Xu, Xiaowei
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2021, 43 (05) : 377 - 380

← 1 2 3 4 5 →