SYNTHESIS OF 1,2,4-TRIAZOLO[4,3-D][1,4]DIAZEPINES AND 1,2,4-OXADIAZOLO[4,5-D][1,4]DIAZEPINES BY 1,3-DIPOLAR CYCLOADDITION

被引：32

作者：

HASNAOUI, A ^{[1
]}

BAOUID, A ^{[1
]}

LAVERGNE, JP ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,SYNTH & ETUD PHYSICOCHIM LAB,CNRS,UA 468,F-34095 MONTPELLIER 2,FRANCE

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 01期

关键词：

D O I：

10.1002/jhet.5570280113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report here a one-step synthesis of the 4,5,6,7-tetrahydro-lH-1,2,4-triazolo[4,3-dI1,4]diazepine, 4-6, and 1,2,4-oxadiazolo[4,5-dIl,4]-diazepine, 7-10, by 1,3-dipolar cycloaddition of nitrile imines and nitrile oxides with 2,3-dihydro-1H-1,4-diazepine, 1. In all cases these cycloadditions are peri- and regioselectives (the C = N bond is sole affected) and occurs with high yields. Structure and conformations of cycloadducts have been assigned by means of nmr analysis.

引用

页码：73 / 76

页数：4

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